The film was theatrically released in the United States on May 12, 2022.
- Tobey Maguire as Patrick Parker: Charles and Michellee' young brave, determined and compassionate son who dreams about being a hero.
- Scarlett Johansson as Natasha Wilde: Patrick's love interest and Norman's servant.
- James Franco as Harry Osborn: Patrick's best friend and wisecracking sidekick and Norman's son.
- Jeff Bridges as Charles Parker: The patriarch of the Parker family, Michelle's husband, and Jeremy, Patrick, and Agnes' father.
- Geena Davis as Michellee Parker: The matriarch of the Parker family, Charles' wife, Jeremy, Patrick, and Agnes' mother, and General of the Resistance.
- Kevin Spacey as Anthony Edward "Tony" Stark: A member of the Resistance and Patrick's mentor.
- Robert Downey Jr. as Johann Schmidt: A small-time thug who plots to become tyrant of Skywalker.
- James Corden as Captain Steve Rogers: A British man from London who visits Skywalker on his vacation and forms a resistance after hearing about evil plans.
- Bradley Cooper as Justin Hammer: Charles' rival weapons manufacturer.
- Chris Pratt as Jeremy Parker: Patrick’s older brother, who is also a secretary at the Skywalker Nuclear Power Plant.
- Bill Hader as Mayor Norman Osborn: Skywalker's merciless, selfish, short-tempered, rude, arrogant and judgmental mayor.
- Gary Oldman as Ron Burgundy: An arrogant and aggressive member of the resistance.
- Ryan Reynolds as Brick Tamland: A nervous member of the resistance who has stage fright.
- Kenan Thompson as Brian Fantana: A scrawny and enthusiastic member of the resistance who has super speed.
- James McAvoy as Champ Kind: A Scottish member of the resistance from Scotland who had sunglasses over his eyes until Patrick licked it.
- Josh Gad as Chuck Diggums: Agnes' comic-relief, cheerful, flamboyant, and long-suffering best friend.
- Sarah Silverman as Agnes Parker: Jeremy and Patrick's younger sister and Michellee and Charles's daughter.
- Jim Carrey as James Buchanan "Bucky" Barnes: Schmidt's second-in-command.
- Danny McBride as Edward "Eddie" Brock, Jr.: Patrick's rival who plots to kill him.
- Ewan McGregor as Martin Brody: The sheriff of Skywalker.
- John Lithgow as Don Xavier: The President of Skywalker.
- Will Smith as Melvin Sterling: A snarky and wise member of the resistance who Jeremy befriends, Janet's boyfriend, and Thurman's best friend.
- Mike Myers as Thurman Schrute: A polite and soft spoken member of the resistance who Jeremy befriends and Melvin's best friend. This film marks Myers' third and final film after his retirement in 2012 and his final film in his lifetime.
- Charlize Theron as Janet Romanoff: A grouchy and sweet-tempered member of the resistance who Jeremy befriends and Melvin's wife.
- Ginnifer Goodwin as Elsa Sneedly: A member of the resistance who is Lando and Franklin's sister.
- Don Cheadle as Lando Sneedly: A member of the resistance who is Elsa and Franklin's brother.
- Jonah Hill as Franklin Sneedly: A member of the resistance who is Elsa and Lando's brother.
- Billy Crystal as Michael "Mike" Wazowski: A wizened, elderly, and slow-moving member of the resistance.
- John Goodman as James P. "Sulley" Sullivan: An elderly, dainty, and kindhearted member of the resistance.
- Seth Rogen as Harold "Harry" Lime: A short and hotheaded thief, Marv's partner in-crime, and Barnes' lieutenant.
- Billy Eichner as Marvin "Marv" Merchants: A tall and dim-witted thief, Harry's partner in-crime, and Barnes' other lieutenant.
- Ilana Glazer as Sarah Cullen: Eugene's daughter who hangs out with Patrick on his visits to her house.
- John Krasinski as Eugene Cullen: The owner of the Skywalker Nuclear Power Plant.
- Bryce Dallas Howard as Marissa Cipher: The President's no-nonsense secretary and Jameson’s love interest.
- Will Ferrell as Scott Lang: A bully to Patrick.
- Marisa Tomei as Veronica Parker: Jeremy's wife.
- Patton Oswalt as Sam Wilson: Eugene's servant at the Skywalker Nuclear Power Plant.
- Simon Pegg as Fegan Floop: The Parkers' ill-tempered and pretentious next-door neighbor, who dislikes his neighbors' constant noisy behavior.
- Robert De Niro as Seymour S. Sassafras: The selfish and malevolent general of the Skywalker Army.
- J. K. Simmons as Jacob Creed: The father of Daisy and Dave who gets hired by Schmidt to capture the Resistance.
- Jacob Tremblay as Sherman Parker: Jeremy and Veronica's son.
- Tessa Thompson as Daisy Creed: Jacob's daughter who helps Jacob capture the Resistance.
- Finn Wittrock as Dave Creed: Jacob's son who reluctant joins Jacob and Daisy on their mission to capture the Resistance.
- Jim Parsons as Assistant Mayor Bucky Romero: The assistant mayor of Skywalker
- John Oliver as Harold "Happy" Hogan: The driver and bodyguard of the Parkers who looks after them.
- Ian McKellen as Dennis Jameson: The most fearsome crime boss in Skywalker.
- Keegan-Michael Key as Adrian Toomes: Schmidt's henchman who pretends to be Patrick's uncle. At the end of the film, he reveals to Patrick that he is Charles' younger brother.
- Sacha Baron Cohen as Francesco Bernoulli: A ruthless bounty hunter sent by Schmidt to capture Rogers.
- Adam Sandler as Toby Seville: William's friend and owner of 7-Eleven who befriends Jeremy.
- Rami Malek as William Bloom: Toby's friend and assistant in 7-Eleven who befriends Jeremy.
- Alan Tudyk as:
- Jack Black as Mr. Alexander "Alex" Minion: A hitman who plots to destroy Patrick and his friends at the start of the movie. According to the audio commentary, he was sent by Schmidt to kill Patrick.
- Alec Baldwin as Alexander Pierce: A Cabinet member and Xavier's secretary.
- Sophia Lillis as Beverly "Bev" Marsh: The only female member of Schmidt's gang who was once a successful fashion designer in Skywalker.
- Jaeden Martell as William "Bill" Denbrough: A member of Schmidt's gang who was a successful mystery novelist in Skywalker.
- Finn Wolfhard as Richard "Richie" Tozier: A bespectacled member of Schmidt's gang who was a successful stand-up comic in Skywalker.
- Chosen Jacobs as Michael "Mike" Hanlon: The only African-American member of Schmidt's gang who was once a librarian in Skywalker.
- Jeremy Ray Taylor as Benjamin "Ben" Hanscom: An overweight member of Schmidt's gang who was an attractive and successful but lonely architect in Skywalker.
- Jack Dylan Grazer as Edward "Eddie" Kaspbrak: A member of Schmidt's gang, a hypochondriac, and a victim of Munchausen syndrome by proxy who was a successful risk assessor for an insurance firm in Skywalker.
- Wyatt Oleff as Stanley "Stan" Uris: A pragmatic member of Schmidt's gang who was a founding partner of a large accounting firm in Skywalker.
- Stephen Tobolowsky as Dr. Gandalf Lehnsherr: A neurosurgeon who was hired by Schmidt to take away Rogers' brain.
- Dan Castellaneta as:
- Homer Simpson: A safety operations supervisor from Sector 7G of the Skywalker Nuclear Power Plant, the spouse of Marge Simpson, and the father of Bart Simpson, Lisa Simpson, and Maggie Simpson.
- Abraham Simpson: The patriarch of the Simpson family and Homer's father.
- Krusty the Clown: The cynical, burnt-out, addiction-riddled smoking clown host of Patrick and Agnes' favorite TV show The Krusty the Clown Show.
- Groundskeeper Willie: The groundskeeper and janitor of Skywalker Elementary School.
- Joe Quimby: One of the Mayor's servants.
- Sideshow Mel: Krusty's sidekick on The Krusty the Clown Show.
- Mr. Teeny: Krusty the Clown’s chain-smoking trained chimp on The Krusty the Clown Show.
- Barney Gumble: The Skywalker town drunk and Homer Simpson's best friend.
- Russ Cargill: Schmidt's bodyguard and chauffer.
- Julie Kavner as:
- Nancy Cartwright as:
- Bart Simpson: The mischievous, rebellious, misunderstood, disruptive and "potentially dangerous" eldest child and Patrick's classmate.
- Maggie Simpson: The 1-year-old, and youngest, child of Marge and Homer.
- Ralph Wiggum: The son of Clancy Wiggum.
- Todd Flanders: The youngest son of Ned Flanders.
- Nelson Muntz: The leader of the school bullies at Springfield Elementary School.
- Edna Krabappel: A high school teacher.
- Martin Prince: A classmate of Patrick and his rival in intelligence.
- Yeardley Smith as Lisa Simpson: Homer and Marge's charismatic 8-year-old daughter and Patrick's friend and classmate.
- Hank Azaria as:
- Moe Szyslak: The proprietor and bartender of "Moe's Tavern".
- Clancy Wiggum: The Sheriff's official deputy.
- Cletus Spuckler: A stereotypical redneck with a good-natured personality.
- Jonathan Frink: Skywalker's local scientist and college professor.
- Apu Nahasapeemapetilon: The operator of the Kwik-E-Mart who speaks with a strong Indian accent.
- Lou: The sheriff's intelligent and competent officer.
- Comic Book Guy: The morbidly obese, geeky proprietor of Skywalker's local comic book store, The Android's Dungeon and Baseball Card Shop.
- Bumblebee Man: The star of a Spanish-language television sitcom on Channel 8, in which he dresses in a bumblebee costume and performs slapstick comedy.
- Carl Carlson: A safety operations supervisor from Sector 7G of the Skywalker Nuclear Power Plant.
- Harry Shearer as:
- Charles Montgomery Burns: The personal assistant owner of the Skywalker Nuclear Power Plant.
- Waylon Smithers: Mr. Burns' self-proclaimed best friend.
- Ned Flanders: Floop's main servant.
- Reverend Timothy Lovejoy: The local Presbylutheran Minister in Skywalker.
- Lenny Leonard: The best friend of Carl Carlson and, along with Carl, second best friend of Homer Simpson, behind Barney Gumble.
- Seymour Skinner: The principal of Skywalker High School.
- Kent Brockman: A local TV news anchorman for Channel 6.
- Julius Hibbert: Springfield's most prominent and competent doctor.
- Otto Mann: A former school underachiever who now drives the school bus for Springfield High School.
- Pamela Hayden as:
On October 9, 2019, directors Anthony and Joe Russo tell producer Sam Raimi that Universal Pictures will make a new film named Skywalker to celebrate the success of Avengers: Endgame with Eric Pearson, Christopher Markus & Stephen McFeely, and Joss Whedon writing it's screenplay. On February 20, 2020, Universal announces that the film will be released on November 8, 2022.
- Main article: Asgard/Soundtrack
On March 20, 2020, the Russo brothers hire Michael Giacchino as their composer for the score of Skywalker.
- Main article: Skywalker/References
- Main article: Skywalker/Tropes
- Main article: Skywalker/Appearances
- Main article: Skywalker/Gallery
- Main article: Skywalker/Credits